Key result
A left-shifted O2 dissociation curve results in higher calculated VO2max compared with the standard ODC when diffusion limitation of O2 transfer occurs at altitude.
Why the study?
Does a shift in the O2 dissociation curve improve exercise tolerance at high altitude in a computer model of pulmonary gas exchange?
Population
Computer model of pulmonary gas exchange
Comparison
Leftward or rightward shift in the O2… vs Standard ODC
Design
Preclinical
Authors
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May enhance modeled VO2max at altitude under diffusion limitation; hypothesis-generating and should not change practice.
Does a shift in the O2 dissociation curve improve exercise tolerance at high altitude in a computer model of pulmonary gas exchange?
The advantage of a leftward versus rightward shift in the oxygen dissociation curve at altitude depends on the presence of diffusion limitation.
Bencowitz et al. (1982) studied Exercise tolerance at high altitude. Leftward or rightward shift in the O2 dissociation curve (ODC) vs. Standard ODC was evaluated on Calculated VO2max and mixed venous PO2 (PVO2). A left-shifted O2 dissociation curve results in higher calculated VO2max compared with the standard ODC when diffusion limitation of O2 transfer occurs at altitude.
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