What question did this study set out to answer?

The study aims to investigate how varying levels of inspired oxygen affect exercise performance and acid-base status.

Oxygen uptake, acid-base status, and performance with varied inspired oxygen fractions

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Randomized trial evaluates performance effects of different oxygen levels during cycling exercise, suggesting acid-base status limits performance.

The study aims to investigate how varying levels of inspired oxygen affect exercise performance and acid-base status.
Six subjects performed cycling exercise at 55% and 90% VO2 max with varied oxygen concentrations (17%, 21%, 60%) during three trials.
Measurements included performance time, gas fractions, ventilation, and arterial blood gases.
Lactate levels and acid-base balance were assessed throughout the exercise sessions.
Performance times were significantly longer in hyperoxia compared to normoxia or hypoxia.
At exhaustion, VO2 levels were similar across all oxygen conditions, indicating oxygen wasn't limiting performance.
Hypoxia increased lactate levels while hyperoxia decreased [H+]a, PCO2, and [HCO3-]a, supporting the notion that acid-base balance could influence performance.

Adams et al. (1980) studied this question.

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Randomized trial evaluates performance effects of different oxygen levels during cycling exercise, suggesting acid-base status limits performance.