Key result
Monte Carlo simulations of a continuous flexible tropomyosin-troponin chain model successfully predicted the stopped-flow transients of myosin-S1 binding to regulated F-actin across a range of calcium concentrations.
A continuous flexible chain model successfully predicts the cooperative binding of myosin-S1 to actin filaments across varying calcium concentrations.
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Validates continuous chain model of thin-filament regulation; leaves open translation to human cardiac mechanics.
Mijailovich et al. (2012) studied Muscle contraction regulation (in vitro/computational). Monte Carlo simulation of continuous flexible Tm-Tn chain was evaluated on Myosin-S1 binding to regulated F-actin. Monte Carlo simulations of a continuous flexible tropomyosin-troponin chain model successfully predicted the stopped-flow transients of myosin-S1 binding to regulated F-actin across a range of calcium concentrations.
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