Key result
Despite treatment with calcium-channel blockers, the incidence of repeat anginal attacks in patients with coronary spastic angina was 37.0% in the first year and 57.5% over the total follow-up period.
Why the study?
Does calcium-channel blocker therapy prevent repeat anginal attacks in patients with coronary spastic angina?
Cohort (n=90)
No
Does calcium-channel blocker therapy prevent repeat anginal attacks in patients with coronary spastic angina?
Despite standard treatment with calcium-channel blockers, a high incidence of repeat anginal attacks persists in patients with coronary spastic angina.
Recurrent symptoms despite CCBs warrant caution in coronary spastic angina management; leaves open whether adjunctive strategies improve control in prospective studies.
BACKGROUND: Calcium-channel blockers (CCBs) are highly effective in suppressing coronary spasm and are widely used as the standard therapy for coronary spastic angina, but it is unclear if CCB treatment completely suppresses the symptoms. METHODS AND RESULTS: The clinical course of the symptoms caused by coronary spasm was investigated in patients taking CCBs: 90 patients were evaluated and 80 patients were followed. The mean follow-up period was 1,796+/-1,169 days. There were no cardiac deaths, but 3 patients were admitted to the hospital, 1 because of the onset of non-Q wave myocardial infarction and 2 because of repeat anginal attacks. In those 2 patients, medical therapy was discontinued at their discretion. In the follow-up analysis, we found that the incidence of symptoms caused by repeat anginal attacks was 37.0% (27/73) in the first year and was increasing every year. CONCLUSIONS: CCBs are strongly recommended for improving the prognosis of coronary spasm, but in many cases they do not suppress completely symptoms.
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Ogawa et al. (2009) conducted a cohort in Coronary spastic angina (n=90). Calcium-channel blockers was evaluated on Incidence of repeat anginal attacks in the first year. Despite treatment with calcium-channel blockers, the incidence of repeat anginal attacks in patients with coronary spastic angina was 37.0% in the first year and 57.5% over the total follow-up period.
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