Key result
Nifedipine retard significantly reduced the cumulative incidence of hospitalization for angina compared to ACE inhibitors in hypertensive patients with previous myocardial infarction (P=0.013).
Why the study?
Does nifedipine retard prevent progression of coronary arteriosclerosis and hospitalization for angina pectoris better than ACE inhibitors in hypertensive Japanese patients with previous MI?
Population
Hypertensive Japanese patients with coronary artery disease and a previous myocardial infarction (MI)
Comparison
Nifedipine retard vs Angiotensin-converting enzyme (ACE) inhibitors
Design
Cohort
Authors
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Nifedipine retard was associated with fewer angina hospitalizations; leaves open preference over ACE inhibitors pending randomized data.
RCT
Yes
Does nifedipine retard prevent progression of coronary arteriosclerosis and hospitalization for angina pectoris better than ACE inhibitors in hypertensive Japanese patients with previous MI?
p-value: p=0.013
Nifedipine retard is more effective than ACE inhibitors in preventing hospitalization for angina pectoris by inhibiting the angiographic progression of coronary artery disease in hypertensive patients with a history of MI.
Yui et al. (2007) conducted an RCT in Hypertension with previous myocardial infarction. Nifedipine retard vs. Angiotensin-converting enzyme (ACE) inhibitors was evaluated on Hospitalization for angina pectoris (p=0.013). Nifedipine retard significantly reduced the cumulative incidence of hospitalization for angina compared to ACE inhibitors in hypertensive patients with previous myocardial infarction (P=0.013).
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