Key result
Isoprenaline augmented calcium and chloride currents and prolonged the action potential to a lesser extent in hypertrophied guinea-pig myocytes compared to controls.
Population
Isolated left ventricular myocytes from guinea-pigs with left ventricular hypertrophy induced by…
Comparison
Isoprenaline (beta-agonist) vs Isolated myocytes from age-matched sham-operated…
Design
Preclinical
Authors
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May heighten re-entrant arrhythmia risk in hypertrophy; hypothesis-generating for beta-adrenergic effects in ventricular remodeling.
In hypertrophied myocytes, isoprenaline induces action potential changes consistent with intracellular ATP depletion, which could enhance the likelihood of re-entrant circuits.
Wallis et al. (2001) studied Left ventricular hypertrophy. Isoprenaline vs. Sham-operated controls was evaluated on Electrophysiological properties (L-type Ca2+ current, Cl- current, action potential morphology). Isoprenaline augmented calcium and chloride currents and prolonged the action potential to a lesser extent in hypertrophied guinea-pig myocytes compared to controls.
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