Population
Ventricular cells from prenecrotic stage 10 to 14 day old hamsters with hereditary cardiomyopathy and…
Comparison
Isoprenaline in varying concentrations, with and… vs Control random bred hamsters and baseline…
Design
Preclinical
Authors
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May heighten arrhythmia risk with isoprenaline in cardiomyopathy; leaves open translation from hamster models to humans.
Young cardiomyopathic hamsters exhibit hypersensitivity to isoprenaline, resulting in prolonged action potential duration, which may contribute to cellular calcium overload and disease progression.
Kenneth L. Rossner (1985) studied this question.
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