Low-dose aspirin-induced upper gastrointestinal bleed and ulceration

We present the case of a 58-year-old male patient who developed upper gastrointestinal bleeding (UGIB) after taking dual antiplatelet therapy (DAPT). He also tested positive for Helicobacter pylori ( H. pylori ) infection. He was on low-dose aspirin (LDA), i.e. 75 mg, as a part of DAPT. In clinical practice, UGIB is a common medical condition that is encountered; its three most frequent causes are peptic ulcer disease (PUD), esophagogastric varices, and erosive esophagitis. H. pylori and aspirin and/or nonsteroidal anti-inflammatory medicine are the two most common causes of PUD. In our case, the patient is a known case of hypertension, diabetes mellitus, and ischemic heart disease. He was diagnosed with multiple gastric ulcers on an upper gastrointestinal endoscopy. He was started on triple therapy for H. pylori and shifted to single antiplatelet therapy from DAPT. In our case, we discuss the factors that could have aggravated the development of multiple gastric ulcers on LDA treatment.