Key result
Elevated high-sensitivity troponin T (≥ 9 ng/L) was significantly associated with impaired mitral annular plane systolic excursion (< 11 mm) assessed by cardiac MRI (OR 4.71).
Why the study?
Do high sensitivity troponin T and I levels correlate with mitral annular plane systolic excursion (MAPSE) assessed by cMRI in patients without right ventricular dysfunction?
Cross-Sectional (n=84)
No
Do high sensitivity troponin T and I levels correlate with mitral annular plane systolic excursion (MAPSE) assessed by cMRI in patients without right ventricular dysfunction?
Odds Ratio: 4.71 (95% CI 1.78–12.51)
p-value: p=0.002
High sensitivity troponin T and I levels inversely correlate with mitral annular plane systolic excursion (MAPSE) and can discriminate impaired MAPSE in patients undergoing cMRI.
PURPOSE: This study aims to evaluate the association between high sensitivity troponins (hsTn) and mitral annular plane systolic excursion (MAPSE) in patients undergoing cardiac magnetic resonance imaging (cMRI). METHODS: Patients undergoing cMRI were prospectively enrolled. Patients with right ventricular dysfunction (< 50%) were excluded. Blood samples for measurements of hsTn and amino-terminal pro-brain natriuretic peptide (NT-proBNP) were collected at the time of cMRI. RESULTS: 84 patients were included. Median left ventricular ejection fraction was 59% (IQR 51-64%). HsTn were correlated inversely with MAPSE within multivariable linear regression models (hsTnI: Beta - 0.19; T - 1.96; p = 0.05; hsTnT: Beta - 0.26; T - 3.26; p = 0.002). HsTn increased significantly according to decreasing stages of impaired MAPSE (p < 0.003). HsTn discriminated patients with impaired MAPSE < 11 mm (hsTnT: AUC = 0.67; p = 0.008; hsTnI: AUC = 0.64; p = 0.03) and < 8 mm (hsTnT: AUC = 0.79; p = 0.0001; hsTnI: AUC = 0.75; p = 0.001) and were still significantly associated in multivariable logistic regression models with impaired MAPSE < 11 mm (hsTnT: OR = 4.71; p = 0.002; hsTnI: OR = 4.22; p = 0.009). CONCLUSIONS: This study demonstrates that hsTn are able to reflect MAPSE being assessed by cMRI.
No takes yet. Share an insight, caveat, or question.
Natale et al. (2017) conducted a cross-sectional in Patients undergoing cardiac magnetic resonance imaging (n=84). High sensitivity troponin T and I vs. Normal or less impaired MAPSE was evaluated on Impaired mitral annular plane systolic excursion (MAPSE) < 11 mm (OR 4.71, 95% CI 1.78-12.51, p=0.002). Elevated high-sensitivity troponin T (≥ 9 ng/L) was significantly associated with impaired mitral annular plane systolic excursion (< 11 mm) assessed by cardiac MRI (OR 4.71).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: