December 1, 1976Journal of VirologyOpen Access

Type C particle-positive and type C particle-negative rat cell lines: characterization of the coding capacity of endogenous sarcoma virus-specific RNA

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Population

Rat cell lines expressing endogenous RNA homologous either to RT21C or to Kirsten sarcoma virus

Design

Preclinical

Authors

ESEdward M. ScolnickBroad Institute DWD. R. WilliamsUniversity of Alabama JMJean MaryakCancer Genetics (United States)

Discussion

Member takes

Implication

Provides mechanistic insight into sarcoma virus formation; leaves open requirements for efficient in vivo transmission.

Structured PICO

Population

Rat cell lines expressing endogenous RNA homologous either to RT21C (a typical rat type C virus) or to Kirsten sarcoma virus

Intervention

Superinfection with heterologous mouse or wooly type C viruses

Outcome

Expression of endogenous RNA, production of structural proteins, and release of type C particlessurrogate

The first step in the genesis of sarcoma viruses involves the packaging of expressed sarcoma virus-specific RNA in helper viral particles, though efficient transmission requires additional events.

Cite This Study

Scolnick et al. (1976) studied this question.

synapsesocial.com/papers/6a242371637bef72baab4148 https://doi.org/10.1128/jvi.20.3.570-582.1976

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Type C particle-positive and type C particle-negative rat cell lines: characterization of the coding capacity of endogenous sarcoma virus-specific RNA

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Type C particle-positive and type C particle-negative rat cell lines: characterization of the coding capacity of endogenous sarcoma virus-specific RNA

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider