December 1, 1974Journal of VirologyOpen Access

Levels of Rat Cellular RNA Homologous to Either Kirsten Sarcoma Virus or Rat Type-C Virus in Cell Lines Derived from Osborne-Mendel Rats

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Population

Cell lines derived from Osborne-Mendel rats and various viruses

Design

Preclinical

Authors

ESEdward M. ScolnickBroad Institute JMJean MaryakCancer Genetics (United States)WPWade P. ParksUniversity of Pittsburgh

Discussion

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Implication

Rat cell data on type-C virus homology warrant no clinical application; leaves open recombination mechanisms in sarcoma virus evolution.

Structured PICO

Population

Cell lines derived from Osborne-Mendel rats (NRK and RT21c cells) and various viruses (V-NRK, RT21c, Moloney leukemia virus, Kirsten sarcoma virus)

Intervention

Molecular hybridization and competition radioimmunoassays of nucleic acids and structural proteins

Outcome

Sequence homology between DNA transcripts from V-NRK and RT21c rat type-C viruses and Kirsten/Harvey sarcoma virusessurrogate

The study demonstrates that rat type-C viruses released from NRK cells incorporate cellular RNA sequences homologous to Kirsten and Harvey sarcoma viruses, providing insight into viral recombination and reassortment.

Cite This Study

Scolnick et al. (1974) studied this question.

synapsesocial.com/papers/6a8c136e167785443dca958b https://doi.org/10.1128/jvi.14.6.1435-1444.1974

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Levels of Rat Cellular RNA Homologous to Either Kirsten Sarcoma Virus or Rat Type-C Virus in Cell Lines Derived from Osborne-Mendel Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Levels of Rat Cellular RNA Homologous to Either Kirsten Sarcoma Virus or Rat Type-C Virus in Cell Lines Derived from Osborne-Mendel Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider