Key result
Mammalian type C viruses specifically package only type C viral RNA, failing to encapsidate type B viral or cellular globin mRNA with comparable efficiency.
Population
Mammalian type C viruses, type B viral RNA, cellular globin mRNA, non-type C mammalian retravirus, and…
Design
Preclinical
Authors
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May aid endogenous retrovirus classification; leaves open applicability to human retroviral vectors or disease models.
The study demonstrates specific mechanisms by which type C viral proteins package type C viral RNA, providing an approach to classify potentially defective endogenous retraviruses.
Goldberg et al. (1976) studied this question. Mammalian type C viruses vs. Type B viral or cellular globin mRNA, MP-MV was evaluated on Specificity and quantitation of the rescue of RNA sequences. Mammalian type C viruses specifically package only type C viral RNA, failing to encapsidate type B viral or cellular globin mRNA with comparable efficiency.
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