What question did this study set out to answer?

To investigate how pituitary-testicular function changes with age in men.

Changes in the Pituitary‐testicular System With Age

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Comprehensive examination of hormonal changes in men with age, highlighting implications for testicular function.

To investigate how pituitary-testicular function changes with age in men.
Studied 466 subjects aged 2 to 101 years
Measured blood levels of LH, FSH, testosterone, oestradiol, SHBG, and hormonal conversion rates
Compared hormonal data with testicular size, sexual function, and secondary sex hair distribution
LH and FSH levels low before puberty, increased in puberty, and progressively after age 40.
Testosterone levels decreased slowly after age 40, while oestradiol levels slightly increased.
Free testosterone and oestradiol levels fell in old age, alongside declining metabolic clearance rates.

Baker et al. (1976) studied this question.

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