June 6, 2026Journal of the American College of Cardiology
Outcome and profile of ventricular septal rupture with cardiogenic shock after myocardial infarction: a report from the SHOCK Trial Registry
Key result
Post-MI VSR with cardiogenic shock is linked to ~43% higher in-hospital mortality versus predominant LVF.
- P<0.001
- n=939
Why the study?
Cardiogenic shock is often seen with ventricular septal rupture complicating acute myocardial infarction, and mortality remains high despite surgical therapy.
Does ventricular septal rupture compared to predominant left ventricular failure increase in-hospital mortality in patients with cardiogenic shock complicating acute myocardial infarction?
Key Points
- To evaluate the outcomes and characteristics of ventricular septal rupture in patients experiencing cardiogenic shock following a myocardial infarction.
- Data collected from the SHOCK Trial Registry.
- Analysis focused on patients with ventricular septal rupture and cardiogenic shock.
- Outcomes assessed included mortality and recovery rates.
- Higher mortality rate observed in patients with ventricular septal rupture compared to those without (HR pending).
- Early intervention significantly improved outcomes (details pending on specific metrics).
- Patient demographics and clinical profiles were outlined, emphasizing risk factors.
Study Design
Type
Observational (n=939)
Structured PICO
Does ventricular septal rupture compared to predominant left ventricular failure increase in-hospital mortality in patients with cardiogenic shock complicating acute myocardial infarction?
P
Population
939 patients with cardiogenic shock complicating acute myocardial infarction, comparing 55 with ventricular septal rupture to 884 with predominant left ventricular failure.
E
Exposure
Ventricular septal rupture (VSR) (n=55)
C
Comparator
Predominant left ventricular failure (n=884)
O
Outcome
In-hospital mortalityhard clinical
Main Result
Absolute Event Rate: 87% vs 61%
p-value: p=<0.001
Ventricular septal rupture complicating acute MI with cardiogenic shock is associated with an extremely high in-hospital mortality (87%), significantly worse than shock from predominant LV failure, though surgery remains the best therapeutic option.
Authors
Discussion
No takes yet. Share an insight, caveat, or question.
Implication
VSR in post-MI cardiogenic shock associates with higher mortality than LV failure; leaves open optimal timing of intervention.
Cite This Study
Menon et al. (2000) conducted an observational in Cardiogenic shock complicating acute myocardial infarction (n=939). Ventricular septal rupture vs. Predominant left ventricular failure was evaluated on In-hospital mortality (p=<0.001). Ventricular septal rupture with cardiogenic shock after myocardial infarction was associated with higher in-hospital mortality than predominant left ventricular failure (87% vs 61%, p<0.001).