Key result
Lower sympathetic nerve activity correlates with increased septal ST-segment elevation in hyperadrenergic POTS.
Why the study?
To determine whether reduced average skin sympathetic nerve activity during sleep was associated with ST-segment elevation in patients with hyperadrenergic postural orthostatic tachycardia syndrome.
Does reduced skin sympathetic nerve activity correlate with nocturnal ST-segment elevation in patients with hPOTS?
Cohort (n=23)
Open-label
No
Does reduced skin sympathetic nerve activity correlate with nocturnal ST-segment elevation in patients with hPOTS?
Reduced skin sympathetic nerve activity during sleep or following clonidine treatment is significantly associated with nocturnal septal ST-segment elevation in patients with hPOTS.
Hyperadrenergic postural orthostatic tachycardia syndrome (hPOTS) is a subgroup of POTS with prominent sympathetic activation symptoms. We recently recorded skin sympathetic nerve activity (SKNA) in ambulatory participants with hPOTS at baseline and after being treated with clonidine.1 We performed a secondary analysis to determine if reduced average SKNA (aSKNA) during sleep was associated with ST elevation.
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Rao et al. (2026) conducted a cohort in Hyperadrenergic postural orthostatic tachycardia syndrome (hPOTS) (n=23). Clonidine vs. Baseline was evaluated on Correlation between changes in ST-segment height and average skin sympathetic nerve activity (aSKNA) (r = -0.57, p=0.003). In participants with hPOTS, there was a significant overall negative correlation (r = -0.57, P = 0.003) between the changes in septal ST-segment height and average skin sympathetic nerve activity.
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