Key result
Brachial-ankle pulse wave velocity was significantly higher in RA patients than healthy controls (1705.44 vs 1386.23 cm/s, P<0.001), and was independently associated with age and triglycerides.
Why the study?
Is brachial-ankle pulse wave velocity increased in Chinese patients with rheumatoid arthritis compared to healthy controls, and what are its determinants?
Cross-Sectional (n=288)
Is brachial-ankle pulse wave velocity increased in Chinese patients with rheumatoid arthritis compared to healthy controls, and what are its determinants?
Absolute Event Rate: 1705.44% vs 1386.23%
p-value: p=<0.001
In Chinese patients with rheumatoid arthritis, arterial stiffness measured by baPWV is significantly increased and independently associated with older age and higher serum triglycerides.
OBJECTIVE: To investigate the relationship between Brachial-ankle pulse wave velocity (baPWV), and its associated risk factors in Chinese patients with RA. METHODS: 138 Chinese RA patients and 150 healthy subjects were included. baPWV of all the participants was measured. RA related factors were determined, as well as traditional cardiovascular risk factors. RESULTS: baPWV was significant higher in RA group (1705.44 ± 429.20 cm/s) compared to the healthy control group (1386.23 ± 411.09 cm/s) (P < 0.001). Compared with low baPWV group, high baPWV group patients were significantly older (P = 0.008) and taller (P = 0.033). Serum cholesterol (P = 0.035), triglycerides (P = 0.004), and LDL level (P = 0.006) were significantly higher in high baPWV group patients compared with low baPWV group patients. The baPWV of RA patients was positively correlated with age (r = 0.439, P < 0.001), and serum cholesterol level (r = 0.231, P = 0.035), serum triglycerides level (r = 0.293, P < 0.001), serum LDL level (r = 0.323, P = 0.003). Meanwhile, baPWV negatively correlated with the height of RA patients (r = -0.253, P = 0.043). Multivariate regression analysis showed that baPWV of RA group was independently associated with age and serum triglycerides level. CONCLUSIONS: The old age and high level of serum triglycerides may be the major determinants of arterial stiffness in Chinese RA patients.
No takes yet. Share an insight, caveat, or question.
Li et al. (2013) conducted a cross-sectional in Rheumatoid Arthritis (n=288). Rheumatoid arthritis vs. Healthy subjects was evaluated on Brachial-ankle pulse wave velocity (baPWV) (p=<0.001). Brachial-ankle pulse wave velocity was significantly higher in RA patients than healthy controls (1705.44 vs 1386.23 cm/s, P<0.001), and was independently associated with age and triglycerides.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: