April 1, 1997FEBS Letters
Binding of the G protein βγ subunit to multiple regions of G protein‐gated inward‐rectifying K+ channels
Population
Cloned mammalian G protein-gated inward-rectifying K+ channel subunits (GIRK1-4)
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Does not support clinical application; extends molecular mapping of GIRK-Gβγ interactions but leaves human relevance open.
Structured PICO
P
Population
Cloned mammalian G protein-gated inward-rectifying K+ channel subunits (GIRK1-4)
I
Intervention
Binding of the G protein betagamma subunit
O
Outcome
Localization of G betagamma binding regions and binding activitiessurrogate
Identifies specific amino acid regions in the N- and C-terminal domains of GIRK subunits responsible for G protein betagamma subunit binding, suggesting domain interactions form higher affinity binding sites.
Cite This Study
Huang et al. (1997) studied this question.