Key result
Type 1 diabetes linked to ~3-fold higher CAC prevalence in women, abolishing the gender gap.
Why the study?
Type 1 diabetes abolishes the gender difference in coronary heart disease mortality, but the pathophysiological basis and whether established risk factors explain this were not understood.
Does type 1 diabetes mellitus abolish the gender difference in coronary artery calcification prevalence?
Population
199 type 1 diabetic patients and 201 nondiabetic participants aged 30 to 55 years
Comparison
Type 1 diabetic patients vs nondiabetic participants
Design
Cross-sectional study
Authors
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May eliminate female protection against coronary calcification in type 1 diabetes; hypothesis-generating and should not yet change risk assessment.
Cross-Sectional (n=400)
Does type 1 diabetes mellitus abolish the gender difference in coronary artery calcification prevalence?
Odds Ratio: 3
p-value: p=0.02
Type 1 diabetes abolishes the protective effect of female gender against coronary artery calcification, largely independent of traditional risk factors.
Colhoun et al. (2000) conducted a cross-sectional in Type 1 diabetes mellitus (n=400). Type 1 diabetes mellitus vs. Nondiabetic participants was evaluated on Coronary artery calcification prevalence (OR 3.0, p=0.02). Type 1 diabetes increased coronary artery calcification prevalence in women (47% vs 21% in nondiabetics) but not men (52% vs 54%), abolishing the gender difference (P=0.002).
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