Women hospitalized with STEMI received less guideline-recommended management and had higher crude 1-year mortality (20.3-28.1%) than men (12.4-17.2%), which attenuated after adjustment.
Observational (n=49,533)
Yes
Are there sex-related differences in the management and mortality of patients hospitalized with STEMI?
Women hospitalized with STEMI in Europe continue to receive less guideline-recommended management and experience higher crude mortality compared to men.
Aims: Data on how differences in risk factors, treatments, and outcomes differ between sexes in European countries are scarce. We aimed to study sex-related differences regarding baseline characteristics, in-hospital managements, and mortality of ST-elevation myocardial infarction (STEMI) patients in different European countries. Methods and results: = 49 533) were included. Cardiovascular risk factors, hospital treatment, and recommendation of discharge medications were obtained from the infarction registries. The primary outcome was mortality, in-hospital, after 30 days and after 1 year. Logistic and cox regression models were used to study the associations of sex and outcomes in the respective countries. Women were older than men (70-78 and 62-68 years, respectively) and received coronary angiography, percutaneous coronary intervention, left ventricular ejection fraction assessment, and evidence-based drugs to a lesser extent than men, in all countries. The crude mortality in-hospital rates (10.9-15.9 and 6.5-8.9%, respectively) at 30 days (13.0-19.9 and 8.2-10.9%, respectively) and at 1 year (20.3-28.1 and 12.4-17.2%, respectively) after hospitalization were higher in women than in men. In all countries, the sex-specific differences in mortality were attenuated in the adjusted analysis for 1-year mortality. Conclusion: Despite improved awareness of the sex-specific inequalities on managing patients with acute myocardial infarction in Europe, country-level data from this study show that women still receive less guideline-recommended management.
Hellgren et al. (Fri,) conducted a observational in ST-elevation myocardial infarction (n=49,533). Female sex vs. Male sex was evaluated on Mortality (in-hospital, 30 days, and 1 year). Women hospitalized with STEMI received less guideline-recommended management and had higher crude 1-year mortality (20.3-28.1%) than men (12.4-17.2%), which attenuated after adjustment.