Key result
Elevated resting heart rate was significantly associated with more severe CAD (p<0.05), lower large HDL (β=-0.073, p=0.024), and higher small LDL subfractions (β=0.103, p=0.005).
Why the study?
Is elevated resting heart rate associated with atherogenic lipoprotein subfractions and severity of coronary artery disease in non-treated patients undergoing coronary angiography?
Observational (n=1,119)
Is elevated resting heart rate associated with atherogenic lipoprotein subfractions and severity of coronary artery disease in non-treated patients undergoing coronary angiography?
Effect estimate: β 0.103
p-value: p=<.05
Elevated resting heart rate correlates with more severe coronary artery disease and an atherogenic lipoprotein profile (lower large HDL, higher small LDL) in treatment-naive patients.
Associated with atherogenic lipids and CAD severity; hypothesis-generating, needs prospective studies before clinical consideration.
OBJECTIVE: To assess the association between resting heart rate (RHR) and lipoprotein subfractions to provide potential evidence for the relationship between RHR and severity of CAD. METHODS: A total of 1119 consecutive non-treated subjects scheduled for coronary angiography were enrolled. High-density lipoprotein (HDL) and low-density lipoprotein (LDL) separation were performed by Lipoprint System. The link of RHR with lipoprotein subfractions was assessed. RESULTS: Increased RHR was significantly associated with higher triglyceride, total cholesterol, non-HDL-cholesterol, and apolipoprotein B (all p < .01). Furthermore, data indicated that higher RHR was related to more severe CAD (all p < .05). In the following linear regression models, we observed that higher RHR (HRh bpm) was significantly associated with lower large HDL (β = -0.073, p = .024) and higher small LDL subfraction (β = 0.103, p = .005) after adjusting for potential confounders. CONCLUSIONS: Increased RHR was associated with more severe CAD, which may be partly due to the significant relation to atherogenic lipoprotein subfractions.
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Zhang et al. (2017) conducted an observational in Coronary artery disease (n=1,119). Elevated resting heart rate vs. Lower resting heart rate was evaluated on Severity of CAD and lipoprotein subfractions (β 0.103, p=<.05). Elevated resting heart rate was significantly associated with more severe CAD (p<0.05), lower large HDL (β=-0.073, p=0.024), and higher small LDL subfractions (β=0.103, p=0.005).
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