Key result
AZD7009 infusion terminated 100% (23 of 23) of induced atrial fibrillation and flutter episodes and prevented reinduction in 19 of 20 attempts in a canine model.
Why the study?
Does AZD7009 infusion terminate induced atrial fibrillation and flutter and prevent reinduction in dogs with sterile pericarditis?
Population
11 dogs with sterile pericarditis undergoing 38 electrophysiologic studies
Design
Preclinical
Authors
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Supports AZD7009 for AF termination in canines; leaves open human translation and requires clinical trials.
Does AZD7009 infusion terminate induced atrial fibrillation and flutter and prevent reinduction in dogs with sterile pericarditis?
AZD7009 is highly efficacious in terminating AF/AFL and preventing reinduction in a canine sterile pericarditis model, demonstrating atrial-selective electrophysiologic effects.
Goldstein et al. (2004) studied Induced atrial fibrillation and flutter (n=11). AZD7009 was evaluated on Termination of induced AF/AFL. AZD7009 infusion terminated 100% (23 of 23) of induced atrial fibrillation and flutter episodes and prevented reinduction in 19 of 20 attempts in a canine model.
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