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April 13, 2010Journal of Cardiovascular Pharmacology

AZD1305 Exerts Atrial Predominant Electrophysiological Actions and Is Effective in Suppressing Atrial Fibrillation and Preventing Its Reinduction in the Dog

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Authors

ABAlexander BurashnikovLankenau Institute for Medical Research AZAndrew C. ZygmuntCincinnati Children's Hospital Medical Center JDJosé M. Di DiegoLankenau Institute for Medical Research

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Implication

May inform atrial-selective antiarrhythmic development; leaves clinical translation from canine models open.

Key Points

Key points are not available for this paper at this time.

Cite This Study

Burashnikov et al. (2010) studied this question.

synapsesocial.com/papers/6a728184febe604dd70aa4ee https://doi.org/10.1097/fjc.0b013e3181e0bc6b

Topics

Persistent AF management Atrial fibrillation AF ablation outcomes Anticoagulation in AF

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Assessment of the Ion Channel-blocking Profile of the Novel Combined Ion Channel Blocker AZD1305 and Its Proarrhythmic Potential Versus Dofetilide in the Methoxamine-sensitized Rabbit In Vivo2009 · 39 citations
2Characterization of the In Vivo and In Vitro Electrophysiological Effects of the Novel Antiarrhythmic Agent AZD7009 in Atrial and Ventricular Tissue of the Dog2006 · 45 citations
3Atrium-Selective Sodium Channel Block as a Strategy for Suppression of Atrial Fibrillation2007 · 400 citations
4Blocking Characteristics of hKv1.5 and hKv4.3/hKChIP2.2 After Administration of the Novel Antiarrhythmic Compound AZD70092005 · 30 citations
5Rapid Conversion of Persistent Atrial Fibrillation to Sinus Rhythm by Intravenous AZD70092009 · 29 citations