What question did this study set out to answer?

To analyze the budget impact and feasibility of implementing anti-amyloid therapies in Italy over three years.

Equity and budget challenges associated with the employment of anti-amyloid monoclonal antibodies for early Alzheimer’s Disease in Italy: A scenario analysis

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Scenario analysis evaluates budget impact and feasibility of anti-amyloid therapies in Italy, suggesting targeted investments for equitable access.

To analyze the budget impact and feasibility of implementing anti-amyloid therapies in Italy over three years.
Conducted deterministic budget modeling.
Utilized Proctor's 8-Domain Implementation Outcomes Framework and CFIR.
Modeled four scenarios based on cumulative patient uptake rates.
Estimated potential eligibility of 42,000 patients for therapy.
Moderate uptake scenario predicts 14,100 patients with a cost of €557.3 million, 33.6% penetration.
Highlights need for infrastructure investment in underserved regions to achieve equitable access.

Giorelli et al. (2026) studied this question.

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Scenario analysis evaluates budget impact and feasibility of anti-amyloid therapies in Italy, suggesting targeted investments for equitable access.