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This study aims to evaluate the impact of various micro-CT analytical parameters on bone loss measurements in a mouse model of peri-implantitis.

June 7, 2026Dentistry JournalOpen Access

Methodological Evaluation of Micro-CT Analytical Parameters for Quantifying Bone Loss in a Murine Maxillary Peri-Implantitis Model

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Randomized trial evaluates micro-CT analysis parameters for quantifying bone loss in mice, suggesting optimal approaches.

This study aims to evaluate the impact of various micro-CT analytical parameters on bone loss measurements in a mouse model of peri-implantitis.
Seventeen C57BL/6J mice were assigned to peri-implantitis (n=8) and healthy (n=9) groups.
Bone loss was assessed using micro-CT scans with varying VOI sizes and threshold values.
Statistical significance was determined using unpaired t-tests or Mann–Whitney U tests.
The 2-thread VOI showed significant bone volume fraction difference (68.86 ± 4.97% vs. 50 ± 4.32%, p < 0.0001, Cohen’s d = 4.05).
The 5-thread VOI did not show a significant difference.
Optimized thresholds selected showed high inter-examiner reliability (Cohen’s kappa = 0.844 and 0.825).

Ginesin et al. (2026) studied this question.

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