2325-P: Temporal Trends in Age-Standardized Diabetes Prevalence in the Americas: A Three-Decade Retrospective Analysis

Introduction and Objective: Diabetes remains a major global burden with rising prevalence. However, consolidated region-level estimates for the Americas are limited, and sex-specific temporal patterns remain under-explored. This study analyzes long-term trends in diabetes prevalence across the Americas using sex-disaggregated data. Methods: Age-standardized diabetes prevalence data from the NCD-RisC dataset for countries in North and South America from 1990-2022 were analyzed by sex. Temporal trends were assessed using Joinpoint Regression to identify significant changes and compute annual percent change (APC) and average annual percent change (AAPC). Results: Age-standardized diabetes prevalence increased from 1990-2022, with distinct sex and country patterns. In North America, males saw steepest rises in Belize and Jamaica, while Mexico declined after 2012. Females showed larger, more persistent increases, though Mexico, Guatemala, and Canada experienced recent declines or stabilization. In South America, nearly all countries showed long-term growth, led by Peru; Venezuela declined after 2014 for both sexes. Female prevalence rose more significantly overall. Conclusion: Diabetes prevalence in the Americas has risen over three decades, with larger increases in females and pronounced growth in South America. Mexico, Canada, and Venezuela show recent stabilization or declines, highlighting the need for sex- and country-specific interventions.