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June 7, 2026Diabetes

3031-LB: An Intestinal mTOR-Gut Microbiota–White Adipose Tissue Axis in Metabolic Regulation

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Authors

HCHannah CeballosZEZhang EryunMCMARIA I. CHOSCO

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Overview

Randomized trial shows intestinal mTOR influences metabolic regulation through gut microbiota in mice, indicating new pathways for treatment.

Key Points

  • The aim is to understand how intestinal mTOR regulates metabolism and impacts conditions like obesity and type 2 diabetes.
  • Generated intestinal epithelium-specific mTOR knockout (mTOR-IKO) mice.
  • Conducted fecal microbiota transplantation from mTOR-IKO to wild-type (WT) mice.
  • Analyzed plasma for metabolic and microbiota changes.
  • mTOR-IKO mice showed enhanced white adipose tissue browning and improved glucose homeostasis compared to WT mice.
  • Fecal transplantation replicated metabolic benefits of mTOR-IKO mice.
  • Altered metabolites associated with tryptophan metabolism were identified in mTOR-IKO plasma.

Cite This Study

Ceballos et al. (2026) studied this question.

synapsesocial.com/papers/6a250b707def13d035e1b79ehttps://doi.org/10.2337/db26-3031-lb
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 12042-LB: The Gut–Fat Cross Talk in Metabolic Regulation through Microbiome2024
  2. 2Constitutive mTORC1 Activation in Skeletal Muscle Increases Inflammation but is not Sufficient to Impair Glucose Tolerance2026
  3. 3Abstract 2117 Crosstalk between nutrient sensor proteins, O-GlcNAc Transferase and mTORC1, is key to regulation of pancreatic β-cell mass and function2024
  4. 4cAMP-MicroRNA-203-IFNγ network regulates subcutaneous white fat browning and glucose tolerance2019 · 28 citations
  5. 5White Adipose Tissue Browning and Cross Talk With Metabolic Diseases and Tumors: From Molecular Mechanisms to Clinical Translation2026