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June 7, 2026

Triglyceride glucose-body mass index as a practical screening tool for metabolic dysfunction-associated steatotic liver disease in older adults: A community-based cohort study.

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Authors

YJYing JiangWHWeiqi HongTXTianwei Xu

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Overview

Community-based cohort study finds TyG-BMI predicts metabolic dysfunction-associated liver disease risk in older adults, indicating its practical use in screening.

Key Points

  • This study aims to evaluate the efficacy of triglyceride glucose-derived parameters, particularly TyG-BMI, in predicting the risk of metabolic dysfunction-associated steatotic liver disease (MASLD) in older adults.
  • Analyzed data from 2,757 Chinese adults aged 60-91 during annual health checks from 2017-2023.
  • Utilized Cox proportional hazards models and time-dependent ROC curves to assess associations and predictive performance of TyG-related parameters.
  • Compared TyG-BMI predictive performance against the hepatic steatosis index (HSI) using ROC analysis.
  • Identified 584 incident MASLD cases over a median follow-up of six years.
  • TyG-BMI showed an adjusted hazard ratio of 6.42 (95% CI: 5.33-7.73) for the highest vs. lowest quartile.
  • TyG-BMI demonstrated higher AUC values than HSI, confirming its superior predictive accuracy.

Cite This Study

Jiang et al. (2026) studied this question.

synapsesocial.com/papers/6a250bca7def13d035e1bd6bhttps://doi.org/10.6133/apjcn.202606_35(3).0017
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The relationship between triglyceride-glucose index, triglyceride-glucose-body mass index, and the severity of hepatic steatosis and liver fibrosis in patients with MASLD: a cross-sectional study2026 · 2 citations
  2. 2Triglyceride Glucose Index and Related Parameters Are Effective Biomarkers to Identify Metabolic Dysfunction-Associated Steatotic Liver Disease Among Egyptian Adults with Type 2 Diabetes2025 · 3 citations
  3. 3Association of triglyceride glucose-body mass index (TyG-BMI) with metabolic dysfunction-associated steatotic liver disease: A systematic review and meta-analysis2025 · 21 citations
  4. 4Triglyceride glucose–body mass index versus conventional lipid ratios for newly detected, ultrasound-defined hepatic steatosis compatible with MASLD: a retrospective cohort study in community-dwelling older adults with type 2 diabetes and hypertension2026
  5. 5Clinical Utility of the Triglyceride–Glucose Index in Assessing Hepatic Steatosis Severity Within the MASLD Spectrum2026