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June 7, 2026Diabetes

1115-OR: Arteriolar Hyalinosis Predicts Long-Term EGFR Decline after Renal Biopsy in Persons with Type 2 Diabetes: A 21±6-Year Follow-Up Study

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Authors

TMTatsumi MoriyaASAkihiko SuzukiAHAkinori Hayashi

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Overview

Randomized trial evaluates eGFR decline predictors in type 2 diabetes, suggesting arteriolar hyalinosis as crucial.

Key Points

  • To determine which renal histological or functional parameters predict eGFR decline in individuals with long-standing type 2 diabetes.
  • Evaluated 33 persons with type 2 diabetes over 21±6 years after renal biopsy.
  • Analyzed glomerular and interstitial structural changes utilizing light and electron microscopy-based morphometric techniques.
  • Measured eGFR slope and annual change in albuminuria during follow-up.
  • Increased arteriolar hyalinosis was significantly associated with eGFR slope (r=0.585, p=0.000).
  • Baseline albuminuria did not predict eGFR slope, and slopes of eGFR were similar for normoalbuminuria and microalbuminuria groups.
  • Multiple regression confirmed arteriolar hyalinosis as the sole independent predictor of eGFR decline (p=0.001).

Cite This Study

Moriya et al. (2026) studied this question.

synapsesocial.com/papers/6a250bca7def13d035e1bd82https://doi.org/10.2337/db26-1115-or
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