2597-P: MetS Phenotypes in Adults with Newly Diagnosed Type 2 Diabetes: Abdominal Obesity as the Main Barrier for Remission

Introduction and Objective: MetS and T2D are closely linked metabolic disorders that have been poorly characterized in the Mexican population. The objective of this study was to evaluate the prevalence, phenotypic patterns, and one-year progression of MetS among adults newly diagnosed T2D in PHC units from Mexico. Methods: We conducted a prospective longitudinal cohort study using the national Chronic Disease Information System (SIC). The analysis included information of 18,232 newly diagnosed T2D patients between 2022 and 2025 and followed-up for 12 months. MetS was defined by 3 or more criteria: abdominal obesity (WHtR ≥0.54 women; ≥0.58 men), hypertension (≥140/90 mmHg), hyperglycemia (≥100 mg/dl), low HDL-C (<50 mg/dl women; <40 mg/dl men), and hypertriglyceridemia (≥150 mg/dl). Progression and remission rates were assessed after 12-months of follow-up. Results: At diagnosis, MetS prevalence was 33.98%, increasing to 50.47% after one year of follow-up. The overall remission rate was 33.11%. Multivariate logistic regression identified abdominal obesity as the strongest independent barrier to remission, reducing the probability of improvement by 75% (OR 0.25, p < 0.001). The highest remission rate was observed in the hypertension + hyperglycemia + low HDL-C phenotype (64.29%), while the lowest remission rate was observed in the abdominal obesity + hypertension + hyperglycemia + low HDL-C + hypertriglyceridemia phenotype (11.86%). Conclusion: MetS prevalence increases rapidly during the first year following T2D diagnosis, driven primarily by the accumulation of abdominal obesity and cardiometabolic risk factors. These findings underscore the need of phenotype-specific interventions at the time of T2D diagnosis within the PHC units of Mexico. Disclosure G. Martinez-Silva: None. A.A. Montoya: None. D. Alvarez-Hernandez: None. R. Garcia-Cerde: None. R. Saucedo-Martinez: None. H.J. Gallardo-Rincon: None. R. Mujica-Rosales: None. R. Tapia-Conyer: None.