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The study aims to validate the Abbott Alinity i TBI test for diagnosing mild traumatic brain injury using blood biomarkers.

June 7, 2026MedicinaOpen Access

Validation of Blood-Based Biomarkers After Mild Traumatic Brain Injury with GCS 15 in a Singapore Emergency Department: An Observational Study

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Observational study validates blood biomarkers for mild TBI diagnosis, suggesting potential for reducing CT use.

The study aims to validate the Abbott Alinity i TBI test for diagnosing mild traumatic brain injury using blood biomarkers.
Conducted as a prospective observational study in a tertiary academic medical center from December 2024 to March 2025.
Included patients aged 21+ with GCS of 15 who sustained head injury within 12 hours and required head CT.
Analyzed UCH-L1 and GFAP levels in plasma collected from whole blood using the Alinity i TBI test.
The overall incidence of positive head CT was 9.2% (11/120), all having positive Alinity i TBI tests.
Sensitivity and negative predictive value for biomarkers were both 100%, with specificity at 13.8%.
GFAP alone showed higher specificity in post hoc analysis at a threshold of 21.1%.

Kuan et al. (2026) studied this question.

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