October 3, 2025Clinical ChemistryOpen Access

A-415 Test Specificity for Intracranial Hemorrhage Improves with Decreasing Age using i-STAT TBI Plasma Test in Adults With Mild Traumatic Brain Injury

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Overall sensitivity for detecting intracranial hemorrhage was 100%, demonstrating high reliability in the evaluated population.
Specificity increased from 29% to 68% in patients under 30, indicating better test accuracy with decreasing age.
Blood tests measuring GFAP and UCH-L1 provide excellent negative predictive value, useful in assessing mild traumatic brain injury.
Adoption of these biomarkers for ruling out CT imaging may benefit health systems, particularly for younger patients or those not on anticoagulants.

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Prospective study reveals increasing test specificity for intracranial hemorrhage in younger adults, suggesting utility of blood biomarkers.

Hoi-Ying Elsie Yu (2025) studied this question.

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Prospective study reveals increasing test specificity for intracranial hemorrhage in younger adults, suggesting utility of blood biomarkers.