A Sustainable Photocatalytic Regioselective Halogenation of 1-Alkyl/Benzyl-3-Phenylquinoxalin-2(1H)-ones in Aqueous Media

Monika Monika; Prashant Kumar; Brajendra K. Singh

doi:10.1039/d6ob00384b

January 1, 2026Organic & Biomolecular Chemistry

A Sustainable Photocatalytic Regioselective Halogenation of 1-Alkyl/Benzyl-3-Phenylquinoxalin-2(1H)-ones in Aqueous Media

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Key Points

This research aims to establish a sustainable and regioselective method for halogenating quinoxalinones.
Developed a photocatalytic protocol for mono-halogenation using 1,3-dihalo-5,5-dimethylhydantoin derivatives as halogen sources.
Employed a dual catalytic system of Pd(OAc)₂ and water-soluble Eosin Y for the reaction.
Conducted the reaction in aqueous media to promote sustainability.
Achieved high regioselectivity in the halogenation of 3-arylquinoxalin-2(1H)-ones.
Showed efficient conversion rates under mild reaction conditions.
Demonstrated the potential of using water as a solvent to improve sustainability outcomes.

Implication

Demonstrates regioselective halogenation in aqueous media, highlighting a sustainable approach.

Abstract

A sustainable and regioselective protocol for mono-halogenation of 3-arylquinoxalin-2(1H)-ones has been developed, utilizing 1,3-dihalo-5,5-dimethylhydantoin derivatives as halogen sources. A dual catalytic system combining Pd(OAc)₂ and water-soluble Eosin Y was employed...

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Cite This Study

Monika et al. (2026) studied this question.

synapsesocial.com/papers/6a250c1c7def13d035e1c241 https://doi.org/10.1039/d6ob00384b

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A Sustainable Photocatalytic Regioselective Halogenation of 1-Alkyl/Benzyl-3-Phenylquinoxalin-2(1H)-ones in Aqueous Media

Key Points

Implication

Abstract

Discussion

Cite This Study

A Sustainable Photocatalytic Regioselective Halogenation of 1-Alkyl/Benzyl-3-Phenylquinoxalin-2(1H)-ones in Aqueous Media

Key Points

Implication

Abstract

Discussion

Cite This Study

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