Mechanistically Orthogonal Radical Strategies Converging on Programmable Site-Selective Halogenation of Quinoxalinones

Q: What does this research mean for the field?

Reagent-programmed C3-, C6-, and C7-halogenation of quinoxalinones can be achieved via two orthogonal radical pathways, including a sunlight-driven PDI photoredox system, that converge on identical products. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Chidananda Biswal; Pravat Nayek; Sandeepan Maity; Prasenjit Mal

doi:10.1039/d6cc01927g

January 1, 2026Chemical Communications

Mechanistically Orthogonal Radical Strategies Converging on Programmable Site-Selective Halogenation of Quinoxalinones

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Key Points

To investigate reagent-programmed site-selective halogenation of quinoxalinones through different radical pathways.
Utilized a sunlight-driven PDI photoredox system to activate inorganic halides.
Implemented moisture-assisted radical pathways for halogenation.
Converged on identical halogenated quinoxalinone products.
Achieved C3-, C6-, and C7-halogenation of quinoxalinones.
Demonstrated effective conversion with high selectivity to the desired products.

Implication

This randomized trial demonstrates site-selective halogenation in quinoxalinones, suggesting innovative synthetic techniques.

Abstract

We report reagent-programmed C3-, C6-, and C7-halogenation of quinoxalinones via two orthogonal radical pathways converging on identical products. A sunlight-driven PDI photoredox system activates inorganic halides, while a moisture assisted...

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Cite This Study

Biswal et al. (2026) studied this question.

synapsesocial.com/papers/6a0d50cdf03e14405aa9ce15 https://doi.org/10.1039/d6cc01927g

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Mechanistically Orthogonal Radical Strategies Converging on Programmable Site-Selective Halogenation of Quinoxalinones

Key Points

Implication

Abstract

Discussion

Cite This Study

Mechanistically Orthogonal Radical Strategies Converging on Programmable Site-Selective Halogenation of Quinoxalinones

Key Points

Implication

Abstract

Discussion

Cite This Study

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