Hybrid adenoid cystic carcinoma of the palate with dual features

Adenoid cystic carcinoma (ACC) is a rare, slowly growing salivary gland neoplasm distinguished by its versatile phenotype and destructive clinical course. Its underlying aetiology is unclear. It is characterised by a gradual yet infiltrative progression, perineural invasion (PNI), a worse prognosis, late recurrence and distant metastases. ACC is recognised for its unique histological features and susceptibility to PNI. We present a case of a female in her 50s with a history of progressively enlarging swelling in the right palate diagnosed as a “hybrid variant of adenoid cystic carcinoma”. Histopathological analysis confirmed the diagnosis, emphasising the need for long-term follow-up given ACC’s propensity for late recurrence and distant spread, particularly to the lungs. For individuals with advanced non-resectable, recurring and/or metastatic illness, there is currently no viable treatment. But its prevalence impedes the advancement of additional studies and clinical investigations to study new approaches and novel treatments.