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June 7, 2026European Journal of PainOpen Access

Oromucosal Administration of a Cannabidiol‐Enriched Cannabis sp. Extract for 2 Weeks Moderately Reduces Cold Hyperalgesia in Rats With Neuropathic Pain

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Authors

RCRaquel Maria Pereira CamposUniversidade Federal do Rio de JaneiroLCLuciana CondeUniversidade Federal do Rio de JaneiroAAAndrey AguiarUniversidade Federal do Rio de Janeiro

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Implication

Randomized trial evaluates oromucosal CBD extract effects on cold sensitivity in rats, suggesting efficacy in pain management.

Key Points

  • This study aims to assess the effects of oromucosal cannabidiol on cold hyperalgesia in a neuropathic pain model using rats.
  • Two-month-old Wistar rats were randomly assigned to CCI and SHAM groups.
  • CBD-enriched extract (10 mg/kg) or vehicle was administered for 15 days post-surgery.
  • Sensitivity assessments included von Frey, acetone, and hot plate tests, along with spinal cord analysis.
  • CCI resulted in thermal hyperalgesia and mechanical allodynia in rats.
  • CBD treatment moderately reduced cold hypersensitivity but did not improve heat sensitivity.
  • No significant changes in immune cell infiltration or cannabinoid receptor expression were observed.

Cite This Study

Campos et al. (2026) studied this question.

synapsesocial.com/papers/6a250c687def13d035e1c8e7https://doi.org/10.1002/ejp.70307
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1International Association for the Study of Pain Presidential Task Force on Cannabis and Cannabinoid Analgesia: research agenda on the use of cannabinoids, cannabis, and cannabis-based medicines for pain management2021 · 59 citations
  2. 2Use of Cannabis and Other Pain Treatments Among Adults With Chronic Pain in US States With Medical Cannabis Programs2023 · 93 citations
  3. 3Effectiveness and tolerability of THC:CBD oromucosal spray as add-on measure in patients with severe chronic pain: analysis of 12-week open-label real-world data provided by the German Pain e-Registry2019 · 63 citations
  4. 4Pharmacokinetics of Cannabidiol in Sprague-Dawley Rats After Oral and Pulmonary Administration2022 · 21 citations
  5. 5Chronic Constriction of the Sciatic Nerve and Pain Hypersensitivity Testing in Rats2012 · 151 citations