What is the clinical evidence from this study?

Study design: Observational. Population: Type 1 diabetes (n=26000000). Intervention: Type 1 diabetes incidence surveillance. Primary outcome: Incident type 1 diabetes.

What does this research mean for the field?

Between 2018 and 2023, the incidence of youth-onset Type 1 Diabetes in the U.S. was higher than prior estimates from 2002-2018, and incidence rates in young adults (aged 18-44) were similar in magnitude to those in youth. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to estimate the incidence of type 1 diabetes (T1D) in individuals aged under 45 years from 2018 to 2023 by age group, race/ethnicity, and sex.

June 7, 2026Diabetes

2379-P: Incidence of Type 1 Diabetes in Persons Aged 45 Years in a Large U.S. Based Surveillance System in 2018–2023

Q: What are the key findings of this study?

In a U.S. surveillance system from 2018-2023, type 1 diabetes incidence was 25.6-31.9 per 100,000 person-years in youth <18 years and 21.6-38.3 per 100,000 person-years in adults aged 18-44 years.

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Key result

U.S. type 1 diabetes incidence reaches ~38 per 100,000 person-years in youth and young adults.

n=26,000,000

Why the study?

While type 1 diabetes incidence has been rising in US children over the past two decades, incidence patterns in young adults remain less known.

Comparison

Incidence rates by age group, race/ethnicity, and sex

Design

Surveillance study

Authors

TCTessa CrumeUniversity of Colorado Anschutz Medical Campus ARANAND RAJAN ABANNA BELLATORRE

Discussion

Member takes

Implication

Updates U.S. T1D incidence surveillance in youth and young adults; leaves open explanations for higher rates than prior estimates.

Key Points

This research aims to estimate the incidence of type 1 diabetes (T1D) in individuals aged under 45 years from 2018 to 2023 by age group, race/ethnicity, and sex.
Utilized the Diabetes in Children, Adolescents, and Young Adults (DiCAYA) Network across six health systems and two geographic sites.
Surveyed over 26 million individuals and identified incident T1D cases via electronic health records.
Calculated incidence rates by age, sex, race/ethnicity, and site type.
Identified 17,461 incident cases of T1D among youth under 18 years, with rates of 25.6 and 31.9 per 100,000 persons per year in health systems and geographic sites, respectively.
In adults aged 18-44 years, noted 28,310 cases with rates of 21.6 and 38.3 per 100,000 persons per year in health systems and geographic sites, respectively.
Observed higher incidence rates in males and significant variations by race/ethnicity, highest in non-Hispanic White and Black youth.

Study Design

Type

Observational (n=26,000,000)

Multicenter

Yes

Structured PICO

Population

Over 26 million individuals aged <45 years surveyed across six health systems and two geographic sites in the U.S. between 2018 and 2023.

Outcome

Incidence of type 1 diabetes (T1D) in 2018-2023

The incidence of type 1 diabetes in the U.S. from 2018-2023 is higher than prior estimates for youth, with young adult-onset rates similar in magnitude.

Cite This Study

Crume et al. (2026) conducted an observational in Type 1 diabetes (n=26,000,000). Type 1 diabetes incidence surveillance was evaluated on Incident type 1 diabetes. In a U.S. surveillance system from 2018-2023, type 1 diabetes incidence was 25.6-31.9 per 100,000 person-years in youth <18 years and 21.6-38.3 per 100,000 person-years in adults aged 18-44 years.

synapsesocial.com/papers/6a250cd27def13d035e1cfdf https://doi.org/10.2337/db26-2379-p

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2379-P: Incidence of Type 1 Diabetes in Persons Aged 45 Years in a Large U.S. Based Surveillance System in 2018–2023

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

2379-P: Incidence of Type 1 Diabetes in Persons Aged 45 Years in a Large U.S. Based Surveillance System in 2018–2023

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Also Consider

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