What does this research mean for the field?

Arterial spin labeling (ASL) MRI-derived renal perfusion shows moderate concordance with gold-standard PAH clearance in healthy controls and type 2 diabetes, suggesting it captures distinct regional hemodynamic information complementary to global clearance. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to evaluate the concordance of multiparametric kidney MRI-derived perfusion measurements with traditional renal plasma flow assessments.

June 7, 2026Diabetes

1402-P: Noninvasive Assessment of Renal Perfusion by MRI and Concordance with Gold-Standard Renal Plasma Flow in Diabetes

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Authors

SRShivani RameshUniversity of Colorado Hospital JWJAMES D. WEISSENKAMPENWaag Futurelab YCYe Ji ChoiUniversity of Washington

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Implication

Randomized trial evaluates renal perfusion using MRI against gold-standard clearance in diabetes, highlighting method implications.

Key Points

This research aims to evaluate the concordance of multiparametric kidney MRI-derived perfusion measurements with traditional renal plasma flow assessments.
Cross-sectional association between pseudocontinuous arterial spin labeling (pcASL) perfusion and p-aminohippurate clearance in 152 participants.
Calculated Total Flow Proxy from MRI data as (Cortical Perfusion Rate × Total Kidney Volume) / 100.
Subgroup analyses conducted for Type 1 Diabetes, Type 2 Diabetes, and Healthy Controls.
Moderate correlation observed between pcASL TF Proxy and effective renal plasma flow (eRPF) (r=0.36, p<0.0001).
Significant correlations noted in Healthy Controls (r=0.41, p<0.0001) and Type 2 Diabetes (r=0.312, p<0.05).
No correlation found in Type 1 Diabetes participants (r=0.24, p>0.05).

Cite This Study

Ramesh et al. (2026) studied this question.

synapsesocial.com/papers/6a250cd27def13d035e1d0ca https://doi.org/10.2337/db26-1402-p

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1402-P: Noninvasive Assessment of Renal Perfusion by MRI and Concordance with Gold-Standard Renal Plasma Flow in Diabetes

Discussion

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Implication

Key Points

Cite This Study

1402-P: Noninvasive Assessment of Renal Perfusion by MRI and Concordance with Gold-Standard Renal Plasma Flow in Diabetes

Discussion

Member takes

Implication

Key Points

Cite This Study

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