Visible-Light-Driven Photocatalyst-Free Synthesis of N-Aryl Amino Acids

Feng Chen; Zhiqin Zhang; Jianwei Wang; Jiaxi Xu; Hongguang Du; Ning Chen

doi:10.1039/d6ob00643d

January 1, 2026Organic & Biomolecular Chemistry

Visible-Light-Driven Photocatalyst-Free Synthesis of N-Aryl Amino Acids

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Key Points

This research aims to develop a new method for synthesizing N-aryl amino acids and unnatural peptides without using catalysts.
Utilized visible light to drive a three-component coupling reaction
Combined glyoxylates, anilines, and 4-alkyl components
Conducted synthesis under mild conditions, leveraging natural sunlight
Successfully synthesized N-aryl amino acids using sunlight with high efficiency
Proved absence of need for traditional catalysts or photocatalysts
Achieved effective coupling outcomes for various 4-alkyl components

Implication

Demonstrates a novel method to synthesize N-aryl amino acids using sunlight, indicating significant advances in green chemistry.

Abstract

A visible-light-driven, three-component coupling for the synthesis of N-aryl amino acids and unnatural peptides is described, which proceeds under mild, catalyst-and photocatalyst-free conditions-even under natural sunlight. Glyoxylates, anilines, and 4-alkyl...

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Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/6a250ce97def13d035e1d240 https://doi.org/10.1039/d6ob00643d

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Visible-Light-Driven Photocatalyst-Free Synthesis of N-Aryl Amino Acids

Key Points

Implication

Abstract

Discussion

Cite This Study

Visible-Light-Driven Photocatalyst-Free Synthesis of N-Aryl Amino Acids

Key Points

Implication

Abstract

Discussion

Cite This Study

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