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June 7, 2026Diabetes

2468-P: Insulin Resistance and β-Cell Function in South vs. East Asians and Caucasians

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Authors

EYEvelyn YandleMLMARJORIE LUZURIAGATMTracey McLaughlin

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Overview

Randomized trial evaluates insulin resistance and beta-cell function in Asians and Caucasians, highlighting significant metabolic differences at lower BMI levels.

Key Points

  • The study aims to evaluate differences in insulin resistance and beta-cell function between nondiabetic South Asians, East Asians, and Caucasians.
  • 371 adult volunteers without diabetes were evaluated at Stanford University.
  • Participants underwent a 3-hour oral glucose tolerance test with insulin and glucose measurements.
  • Insulin secretion was assessed using the insulinogenic index and the disposition index for beta-cell function.
  • Asians showed higher glucose levels at all OGTT time points compared to Caucasians, with greater insulin resistance at BMI <27 kg/m².
  • South Asians exhibited greater insulin resistance, while East Asians experienced more hyperglycemia without impaired beta-cell function.
  • At BMI >27 kg/m², differences between racial groups were minimal with slightly higher glucose levels in Asians.

Cite This Study

Yandle et al. (2026) studied this question.

synapsesocial.com/papers/6a250ce97def13d035e1d30bhttps://doi.org/10.2337/db26-2468-p
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 144-PUB: Evaluation and Care of Double Diabetes in Asian American Patients2026
  2. 2Insulin Hypersecretion and Increased Ectopic Fat in South Asian American Adolescents and Young Adults Compared With White and African American Peers: The CHARISMA Study2026
  3. 32253-P: Asian Ancestry and Higher Predicted 10-Year Type 2 Diabetes Risk: Greater Insulin Resistance and Lower β-Cell Function2026
  4. 4Body Fat Distribution and Insulin Resistance in Healthy Asian Indians and Caucasians2001 · 523 citations
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