Why the study?
Does myocardial infarction alter the electrophysiological properties and stretch sensitivity of atrial fibroblasts, contributing to bradyarrhythmia?
Population
Rats with myocardial infarction induced by coronary artery ligation and sham-operated rats
Comparison
Myocardial infarction via coronary artery ligation vs Sham operation
Design
Preclinical
Follow-up
Up to 30 days (evaluated at 8, 20, and 30 days)
Authors
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May implicate atrial fibroblasts in post-MI bradyarrhythmia; hypothesis-generating and leaves human translation open.
Does myocardial infarction alter the electrophysiological properties and stretch sensitivity of atrial fibroblasts, contributing to bradyarrhythmia?
Changes in the susceptibility of atrial fibroblasts to mechanical stretch may contribute to bradyarrhythmia during postinfarct remodeling.
Kamkin et al. (2002) studied this question.
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