Population
Mice lacking the Cyp27 gene (Cyp27(-/-)) and wild-type controls (Cyp27(+/+))
Comparison
Disruption of the sterol 27-hydroxylase gene… vs Cyp27(+/+) wild-type controls
Design
Preclinical
Authors
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Cyp27 disruption links to lipid dysregulation in mice; leaves open human relevance and requires prospective validation.
Disruption of the sterol 27-hydroxylase gene in mice leads to hepatomegaly, hypertriglyceridemia, and altered cholesterol and bile acid synthesis, revealing its role in triacylglycerol metabolism.
Repa et al. (2000) studied this question.
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