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April 1, 1987Journal of Biological ChemistryOpen Access

Control of filament length by the regulatory light chains in skeletal and cardiac myosins.

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Population

Rabbit skeletal and dog cardiac myosins (in vitro model)

Comparison

Removal of regulatory light chains (LC2) vs Control and LC2-recombined samples

Design

Preclinical

Authors

SMSarkis S. MargossianTHTed W. HuiattHSHenry S. Slayter

Discussion

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Overview

LC2's role in filament assembly is hypothesis-generating for sarcomere-targeted research; leaves open any clinical relevance in human cardiomyopathy.

Structured PICO

P
Population
Rabbit skeletal and dog cardiac myosins (in vitro model)
I
Intervention
Removal of regulatory light chains (LC2)
C
Comparator
Control and LC2-recombined samples
O
Outcome
Synthetic thick filament length and structuresurrogate

Regulatory light chains (LC2) play an active role in controlling synthetic thick filament length in both skeletal and cardiac muscles.

Cite This Study

Margossian et al. (1987) studied this question.

synapsesocial.com/papers/6a25f63227c192cf30cfdecchttps://doi.org/10.1016/s0021-9258(18)45644-x
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Also Consider

Synapse has enriched one closely related paper. Consider it for comparative context:

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