May 1, 1991The Journal of Cell BiologyOpen Access

Effects of phosphorylation by myosin light chain kinase on the structure of Limulus thick filaments.

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Population

Limulus telson muscle thick filaments

Design

Preclinical

Authors

RLRhea J. C. LevineAllegheny College PCPeter D. ChantlerRoyal Veterinary College RKRobert W. KenslerUniversity of Puerto Rico System

Discussion

Member takes

Implication

MLCK filament effects remain preclinical; hypothesis-generating for myosin regulation and leaves open mammalian cardiac relevance.

Structured PICO

Population

Limulus telson muscle thick filaments

Intervention

Phosphorylation of myosin regulatory light chains by myosin light chain kinase (MLCK)

Outcome

Changes in thick filament structure (disordering of helical surface arrangement, distal bends and breaks, production of shorter filaments and end-fragments)surrogate

Phosphorylation of regulatory myosin light chains by MLCK induces outward movement of myosin heads and thick filament shortening in Limulus muscle.

Cite This Study

Levine et al. (1991) studied this question.

synapsesocial.com/papers/6a86da2eed1c9801b3cf873c https://doi.org/10.1083/jcb.113.3.563

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Effects of phosphorylation by myosin light chain kinase on the structure of Limulus thick filaments.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of phosphorylation by myosin light chain kinase on the structure of Limulus thick filaments.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider