Population
Limulus (horseshoe crab) myosin preparation
Comparison
Calcium-calmodulin-dependent phosphorylation of… vs Unphosphorylated myosin
Design
Preclinical
Authors
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Animal data warrant no clinical change; extends invertebrate myosin mechanisms while leaving human cardiac translation open.
Demonstrates that Limulus myosin is regulated by calcium-calmodulin-dependent phosphorylation of its regulatory light chains, which increases actin-activated MgATPase activity.
James R. Sellers (1981) studied this question.
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