Key result
Lower left ventricular ejection fraction (tertile 3) was associated with an increased risk of poor functional outcome and mortality in acute ischemic stroke patients.
Why the study?
Few studies have evaluated the impact of lower LVEF on the prognosis of patients with acute ischemic stroke.
Does lower LVEF predict poor functional outcome and mortality in patients with acute ischemic stroke?
Cohort (n=283)
No
Does lower LVEF predict poor functional outcome and mortality in patients with acute ischemic stroke?
Answers are grounded in this paper and cite their sources.
Decreased LVEF predicts an inferior prognosis, including poor functional outcome and mortality, in patients with acute ischemic stroke.
As few studies have reported the impact of lower left ventricular ejection fraction (LVEF) on the prognosis of acute ischemic stroke (AIS) patients, we aimed to explore this through a retrospective cohort study and a meta-analysis. A total of 283 AIS patients receiving intravenous thrombolysis at the Third Affiliated Hospital of Wenzhou Medical University between 2016 and 2019 were enrolled and divided into three groups based on LVEF tertiles. The logistic regression model estimated the association between LVEF and the three-month AIS prognosis. After adjusting for confounding factors, patients in tertile 3 exhibited an increased risk of poor functional outcome and mortality [odds ratio (OR), 2.656 (95% CI: 1.443-4.889); OR, 7.586 (95% CI: 2.102-27.375)]. A systematic search of PubMed, EMBASE and Cochrane Library was performed. Our meta-analysis revealed that LVEF < 40% was significantly associated with poor functional outcome [OR 1.94 (95% CI: 1.08-3.50)], mortality [OR 3.69 (95% CI: 1.22-11.11)], as well as LVEF < 55% [OR 1.68 (95% CI: 1.22-2.32); 2.27 (95% CI: 1.30-3.96)], respectively. A decreased LVEF could predict an inferior prognosis for AIS; therefore, it could aid in clinical decision-making in this patient population.
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Yang et al. (2024) conducted a cohort in Acute ischemic stroke (n=283). Lower left ventricular ejection fraction (tertile 3) vs. Higher left ventricular ejection fraction (tertiles 1 and 2) was evaluated on Poor functional outcome (OR 2.656, 95% CI 1.443-4.889). Lower left ventricular ejection fraction (tertile 3) was associated with an increased risk of poor functional outcome and mortality in acute ischemic stroke patients.
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