Key result
Higher left ventricular ejection fraction was associated with a significantly lower risk of major adverse cardiac events (HR 0.54 per 10% increase) after acute ischemic stroke in patients without atrial fibrillation or coronary heart disease.
Why the study?
Does reduced LVEF predict MACE and all-cause mortality in patients with acute ischemic stroke without atrial fibrillation and coronary heart disease?
Cohort (n=1,465)
No
Does reduced LVEF predict MACE and all-cause mortality in patients with acute ischemic stroke without atrial fibrillation and coronary heart disease?
Hazard Ratio: 0.54 (95% CI 0.36–0.8)
p-value: p=0.002
Reduced LVEF is an independent predictor of cardiovascular events and mortality after acute ischemic stroke, even in patients without atrial fibrillation or coronary heart disease.
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May aid LVEF-based risk stratification after acute ischemic stroke without AF/CHD; leaves open whether reduced LVEF is causal or modifiable.
Lee et al. (2018) conducted a cohort in Acute ischemic stroke or transient ischemic attack without atrial fibrillation and coronary heart disease (n=1,465). Left ventricular ejection fraction (per 10% increase) was evaluated on Major adverse cardiac events (MACE) (HR 0.54, 95% CI 0.36-0.80, p=0.002). Higher left ventricular ejection fraction was associated with a significantly lower risk of major adverse cardiac events (HR 0.54 per 10% increase) after acute ischemic stroke in patients without atrial fibrillation or coronary heart disease.
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