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Reveals MHC class II is crucial for preventing autoimmunity via cross-presented antigens in cDC1s, indicating a need for regulatory T cell interactions.
T cell effectors from the cutaneous draining lymph nodes abrogated the autoimmune condition. Therefore, our results revealed that the cross-tolerizing capacity of cDC1s is not a property fully acquired at the time they undergo homeostatic maturation but needs to be enforced via MHCII-restricted, suppressive interactions with regulatory T cells.
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Wohn et al. (2020) studied this question.
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