Key result
Interprofessional collaboration optimizes DOAC management in older adults with polypharmacy to prevent serious drug interactions.
Why the study?
DOAC drug-drug interactions can compromise safety and efficacy in older adults, who commonly have polypharmacy and heightened risks of major bleeding.
Interprofessional team collaboration is essential for managing the risks of drug-drug interactions associated with DOAC use in older adults with polypharmacy.
Alerts clinicians to interaction risks in geriatric polypharmacy; leaves open optimal team-based mitigation strategies.
Direct oral anticoagulants (DOACs) have been increasingly used by older adults. Although these medications offer several therapeutic advantages over traditional anticoagulants, such as warfarin, they have limitations. One significant concern associated with DOACs is their potential for drug–drug interactions. These interactions may compromise the safe and effective use of DOACs and can potentially lead to serious adverse events and complications, particularly major bleeding. Polypharmacy is common among older adults with chronic diseases, which can increase the risk of drug–drug interactions with DOACs. The current article discusses the impact and risks of drug–drug interactions with DOACs in the context of older adults and explores ways to improve and manage these interactions through the collaboration of an interprofessional team. [ Journal of Gerontological Nursing, 49 (9), 7–13.]
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Tran et al. (2023) conducted a review in Drug-drug interactions with DOACs. Direct oral anticoagulants (DOACs) was evaluated. Drug-drug interactions with direct oral anticoagulants in older adults with polypharmacy can lead to serious adverse events, requiring interprofessional team collaboration for optimal management.
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