Key result
Perioperative goal-directed therapy was evaluated in 112 randomised trials, but substantial clinical heterogeneity precluded a meta-analysis of all-cause mortality.
Why the study?
Does perioperative goal-directed therapy reduce all-cause mortality in surgical patients?
Systematic Review (n=112)
Does perioperative goal-directed therapy reduce all-cause mortality in surgical patients?
Clinical heterogeneity in perioperative goal-directed therapy trials is too large to perform a meaningful meta-analysis, highlighting the need for universally agreed definitions.
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Excessive heterogeneity in goal-directed therapy trials precludes mortality meta-analysis; leaves open efficacy and demands standardized protocols.
Kaufmann et al. (2018) conducted a systematic review in Perioperative (n=112). Perioperative goal-directed therapy was evaluated on All-cause mortality. Perioperative goal-directed therapy was evaluated in 112 randomised trials, but substantial clinical heterogeneity precluded a meta-analysis of all-cause mortality.
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