Key result
Aneurysmal rebleeding occurs significantly more frequently within the first 6 hours after the initial hemorrhage (OR 3.22) and is associated with high systolic blood pressure and poor Hunt-Hess grade.
Why the study?
Do specific clinical and anatomical risk factors increase the rate of rebleeding in patients with aneurysmal subarachnoid hemorrhage?
Meta-Analysis (n=5,693)
Do specific clinical and anatomical risk factors increase the rate of rebleeding in patients with aneurysmal subarachnoid hemorrhage?
Answers are grounded in this paper and cite their sources.
Aneurysmal rebleeding occurs most frequently within the first 6 hours after initial hemorrhage and is significantly associated with high systolic blood pressure, poor Hunt-Hess grade, hematomas, posterior circulation, and aneurysm size >10 mm.
BACKGROUND: Rebleeding is a serious complication of aneurysmal subarachnoid hemorrhaging. To date, there are conflicting data regarding the factors contributing to rebleeding and their significance. METHODS: A systematic review of PubMed and Embase databases was conducted for studies pertaining to aneurysmal subarachnoid hemorrhage (aSAH) and rebleeding in order to assess the associated risk factors. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated from fourteen studies comprised of a total of 5693 patients that met the inclusion criteria. RESULTS: Higher rebleeding rates were observed < 6 h after the initial aSAH (OR = 3.22, 95% CI = 1.46-7.12), and were associated with high systolic blood pressure (OR = 1.93, 95% CI = 1.31-2.83), poor Hunt-Hess grade (III-IV) (OR = 3.43, 95% CI = 2.33-5.05), intracerebral or intraventricular hematomas (OR = 1.65, 95% CI = 1.33-2.05), posterior circulation aneurysms (OR = 2.15, 95% CI = 1.32-3.49), and aneurysms >10 mm in size (OR = 1.70, 95% CI = 1.35-2.14). CONCLUSIONS: Aneurysmal rebleeding occurs more frequently within the first 6 hours after the initial aSAH. Risk factors associated with rebleeding include high systolic pressure, the presence of an intracerebral or intraventricular hematoma, poor Hunt-Hess grade (III-IV), aneurysms in the posterior circulation, and an aneurysm >10 mm in size.
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Tang et al. (2014) conducted a meta-analysis in Aneurysmal subarachnoid hemorrhage (n=5,693). Time < 6 hours after initial aSAH vs. Time > 6 hours after initial aSAH was evaluated on Rebleeding (OR 3.22, 95% CI 1.46-7.12). Aneurysmal rebleeding occurs significantly more frequently within the first 6 hours after the initial hemorrhage (OR 3.22) and is associated with high systolic blood pressure and poor Hunt-Hess grade.
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